منابع مشابه
Presynapses go nuclear!
Decades of research has shown that long-term changes in synaptic function ultimately require changes in gene expression.Recent work has focused on nuclear signaling by calcium and protein messengers initiated at postsynaptic sites. In this issue of The EMBO Journal, Ivanova and colleagues show that shuttling of CtBP-1 between presynaptic areas and nuclei regulates gene expression, which reminds...
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We can deplete it, we have the technology ore can be more, based on two comprehensive RNAi studies of motors and actin-regulating proteins in fly S2 cells—a particularly robust system for RNAi techniques and a convenient cell type for cytological studies. The first of the two papers, by Goshima and Vale (page 1003), examines the role of every fly kinesin during mitosis—the first such study done...
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Mutations in nuclear lamins or other proteins of the nuclear envelope are the root cause of a group of phenotypically diverse genetic disorders known as laminopathies, which have symptoms that range from muscular dystrophy to neuropathy to premature aging syndromes. Although precise disease mechanisms remain unclear, there has been substantial progress in our understanding of not only laminopat...
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The virus world in which we live will never cease to amaze us. Historically, viruses were studied primarily from medical and economic perspectives; however, the last decades have shown that viruses play roles far more versatile than we could have imagined. Being the most abundant biological entities on the planet (there are ∼10 virus particles in every liter of seawater), viruses drive biogeoch...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2015
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.201591331